Cancer and Oxygen

 
 
 
 

Vocabulary

 

seal	regulate	good/better/best
limit	wisdom	mission (2)
focus	breathe	neurological
diver	research	lead/led/led (2)
solve	oxygen	specialize
evade	potential	advantage
seizure	damage	detection
bubble	undersea	pressure (2)
ability	strategy	mitigation
fund	prevent	microscope
install	simulate	subject (4)
neuron	chamber	demonstrate
brain	resistant	metabolism
severe	epilepsy	medication
anti-	patient (2)	side effect
SEAL	sharp (2)	intervention
reduce	regulate	carbohydrate
severe	damage	transport (2)
fail	level (3)	therapeutic
prove	effective	alternative
cure	pretty (2)	approach (2)
lack	disorder	Nobel Prize
exploit	pediatric	know/knew/known
adapt	primary	hypothesis
fuel	hybrid (2)	supplement
restrict	model (3)	circumvent
ketone	pioneer	application
inspire	observe	Achilles’ heel
sustain	attention	give/gave/given
uptake	syndrome	win/won/won
enemy	validate	demonstrate
prove	secondary	experiment
defect	target (2)	prevention
variety	oncology	consumption
excess	radical (2)	relative (2)
allow	modality	demonstrate (2)
thrive	region (2)	proliferate
glucose	surround	make/made/made
scan	promising	give/gave/given
bump	hyperbaric	membrane
surface	indicative	combination
elevate	metastatic	magnification
glow	path (2)	produce (2)
spread	start out	free radical
strategy	incurable	supplement
	dependent	fall back on

 
 
 
 
 

Video

 

 
 
 
 

Transcript

Navy SEAL divers are the best at what they do. But they have a problem that limits their ability to do their mission.

Our research focused on solving the problem and it led to an unexpected path of discovery for neurological diseases and cancer.

The problem results from the specialized equipment that the Navy SEAL divers use, including the oxygen rebreather. The advantage of the rebreather is that there are no bubbles so it’s very quiet and helps the SEAL evade detection from the enemy.

The disadvantage of the oxygen rebreather is that the high levels of oxygen and the pressure from the undersea environment causes a potential for a seizure.

These seizures occur with little or no warning and there is no effective mitigation strategy to prevent them.

So the question we ask is why do the seizures occur and how can we prevent them?

To answer this question required funding from the Office of Naval Research to develop a microscope that was installed inside a hyperbaric chamber, or a high-pressure chamber. This chamber could simulate the underwater environment and the pressure of the underwater environment.

Using this technology we demonstrated that neurons in the brain, when subjected to high pressure and high oxygen, are overstimulated. The overstimulation of the brain from the high oxygen and pressure causes a decrease in brain energy metabolism.

When this happens, it causes the potential for a seizure. These oxygen seizures occur with little or no warning — and there is no effective way to prevent them.

These drug resistant seizures are similar to epilepsy patients that have drug resistant seizures, and in the case of patients they can use a special diet to prevent these seizures.

. . . . . . . .

One example of the patient who used diet is Mike Dancer. Mike used a variety of antiseizure medication, and the medication caused severe side effects and was not able to control his seizures.

So, due to the severe side effects, Mike stopped all the antiseizure medication and when he did it, he saw an increase in his seizure frequency.

. . . . . . . .

At about this time Mike discovered there was is a dietary intervention, that he could use to control his seizures. And when he did it, he found a sharp decrease in his seizure frequency.

I’m happy to say that Mike has been on the diet for 5 years now, and he’s been managing his epilepsy for 5 years without medication.

So what is the ketogenic diet? Compared to a normal diet, the ketogenic diet is very low in carbohydrates and it’s very high in fat. People have used the diet for years to help them regulate their body weight, reduce their body weight, and control or reduce their blood glucose levels.

But most importantly, the ketogenic diet is proven to control seizures, when drugs fail. No organization has done more to educate the public about therapeutic potential of the ketogenic diet than The Charlie Foundation, started by Hollywood producer Jim Abrahams.

. . . . . . . .

Jim’s son Charlie was stricken with seizures. They were so severe and no amount of drugs could help him. So Jim looked into alternative approaches to manage his son’s seizures. And with his research he discovered that the ketogenic diet was being used at Johns Hopkins Hospital, so it was a treatment that was used specifically for pediatric epilepsy.

So Jim took Charlie to Johns Hopkins Hospital and they worked pretty closely with a dietician there, and within a short amount of time Charlie’s seizures were under control. And Charlie was actually cured of his epilepsy at Johns Hopkins Hospital with the use of the ketogenic diet.

So Charlie is actually off the diet completely today, and he remains seizure-free. The ketogenic diet is effective for a variety of neurological disorders including Glucose Transporter Type 1 Deficiency Syndrome. Children with this disorder lack the ability to transport glucose into the brain.

So their brains are literally starved of glucose and this causes a potential for seizures. So it’s known that, you know, the brain can use glucose as the primary fuel, but it can readily adapt to using ketones for energy.

So in this way the brain is like a hybrid engine, right? So it uses glucose as the primary fuel but during periods of limited glucose availability the brain can readily adapt to using this alternative fuel source.

So we are exploiting the neuroprotective effects of ketones by developing ketone supplements for the Navy SEAL divers for oxygen seizures. So the advantage of the ketone supplement is that you can circumvent the need for the dietary restriction that’s required to elevate and sustain blood levels of ketones.

There are many therapeutic applications of ketones because nearly all healthy cells in a body can use ketones for fuel as an alternative energy source.

Surprisingly, cancer cells lack the ability to transition from using glucose for fuel to using ketones. So, in a way, cancer cells are like damaged hybrid engines. They use large amounts of glucose, much more than healthy cells, and they lack this ability to transition over to an alternative fuel source.

. . . . . . . .

So we can say that “sugar addiction” is really the Achilles heel of cancer cells. This observation inspired me in the lab, and I asked a question, I wondered, why very little attention was being given to nutrition to exploit this weakness of cancer cells.

So, it turns out that the sugar addiction was actually observed over 80 years ago by Otto Warburg. So, Otto Warburg did experiments, he won a Nobel prize for these experiments, demonstrating that [cancer] cells are damaged in their metabolism and the damage in their metabolism results in high amounts of sugar uptake.

More recently, Thomas Seyfried from Boston College has been a pioneer, really, in validating Warburg’s hypothesis and proving that cancer is a metabolic disease. In Tom’s experiments, he demonstrated that there is a specific, metabolic defect of cancer cells as glucose dependency, and that we can target that with a variety of non-toxic alternative approaches.

Oncologists target this weakness in cancer cells, which is excess glucose consumption, with something called a FGD-PET Scan. The PET Scan actually shows the excess consumption of glucose in cancer cells relative to the healthy tissues surrounding it. So this allows for the imaging of excess glucose consumption that oncologists use.

But this information really isn’t used to exploit the cancer for a treatment modality. The excess glucose consumption of cancer cells allows them to thrive and proliferate in a low oxygen environment.

. . . . . . . .

Another interesting observation that we made in the lab is that high pressures of oxygen are actually damaging to cancer cells. We’ve demonstrated that when high levels of oxygen are given to cancer cells that they overproduce oxygen free radicals, and these are damaging to the cell membrane.

At high magnification we can observe bumps on the surface of the membrane that are indicative of membrane damage. What’s most interesting is that the same level of oxygen that damaged the cancer cells was non-toxic to the healthy brain cells.

These observations inspired us to test the combination of the ketogenic diet and hyperbaric oxygen in a mouse model of metastatic cancer. The glowing regions on the screen, show the growth and the spread of metastatic cancer cells.

This study demonstrated the therapeutic efficacy of a new, non-toxic, alternative approach to cancer management.

So what started out as a Navy SEAL project and then led to a promising mitigation strategy for the oxygen seizures in the form of ketone supplements ultimately led us down a path to this unexpected discovery.

So the question is, can we manage cancer with non-toxic strategies? I believe that we can. And I’ve been inspired by a number of seizure patients and cancer patients that have used these alternative methods to manage their incurable diseases.

Future treatments and prevention of many diseases may fall back on the ancient wisdom of Hippocrates, when he said, “Let food be thy medicine.” Thank you.

*     *     *     *     *     *     *

Questions

Hurt. Navy Seals only engage in urban, anti-terror operations. True or false?

Wound. Do they use ordinary aqualungs (scuba tanks) when scuba diving? What are the advantages and disadvantages of the re-breather?

Injury. What causes seizures in the Navy Seal divers? Is there an analogy in the real world?

Cancer. Are there antidotes, medications or other cures or treatments for seizures?

Arteriosclerosis. Charlie was cured of his epilepsy through surgical intervention. Is this right or wrong?

Cardiac Arrest. In order for the human brain to function, does it need and feed on glucose, exclusively?

Stroke. Only the brain uses glucose and ketones as fuel. Is this correct or incorrect?

Fracture. Did the speaker make the discovery about the relationship between cancer cells and sugar?

Suffocate. How do you compare the relationship between glucose, ketones, normal cells and cancer cells?

Hunger. Oxygen has no affect on normal cells and cancerous cells. Yes or no?

Starvation. Did the speaker end his talk with a conclusion?
 
 
 
Coronary Heart Disease. Cancer is a serious health problem in my community. True or false? Is it a leading cause of death?

Common Cold. Does the public dread cancer? How do they feel about it?

Flu. What may be the causes of cancer? Do cancer rates differ in different regions and different segments of the population?

Pneumonia. Is there much public discourse on cancer? Is there much cancer research?

Measles. What might happen in the future?

Hepatitis. What are some possible solutions or cures for cancer?